Effect of a novel carbonate apatite in combination with fibroblast growth factor (FGF)-2 on periodontal regeneration

Effect of a novel carbonate apatite in combination with fibroblast growth factor (FGF)-2 on periodontal regeneration - Effect of FGF-2 and carbonateapatite on periodontal regeneration

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000040783

Enrollment

Registered

2020-09-01

Start date

2020-10-20

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodontitis

Interventions

Use of FGF-2 (REGROTH) during periodontal surgery Use of FGF-2 (REGROTH) plus carbonate apatite (Cytrans) during periodontal surgery

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with periodontitis who have completed initial periodontal therapy and: 1. with probing depth <= 4 mm 2. with vertical bone defect <= 3 mm

Exclusion criteria

Exclusion criteria: Patients with uncontrolled systemic diseases, those with allergic reactions to FGF-2, Bio-Oss, or Cytrans those with (or had) oral malignant tumor, in pregnancy or nursing, those receiving anti-coagulant drugs or any other drugs that may influence the clinical results.

Design outcomes

Primary

Measure	Time frame
Gain in Clinical Attachment level (at 12 months after intervention)	—

Secondary

Measure	Time frame
Probing depth Bleeding on probing Tooth mobility Radiographic bone level Oral health-related QoL score	—

Countries

Japan

Contacts

Public ContactAtsushi Saito

Tokyo Dental College Department of Periodontology

atsaito@tdc.ac.jp03-6380-9172

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026