The investigation of the relationship between coronary atherosclerosis and clinical data

The investigation of the relationship between coronary atherosclerosis and clinical data - Analysis of coronary atherosclerosis by single cell RNA sequencing

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000040747

Enrollment

Registered

2020-06-15

Start date

2020-10-22

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary atherosclerosis

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: (1) Patients 20 years of age or older at the time of percutaneous coronary intervention(PCI) (2) Patients who underwent PCI with directional coronary atherectomy and had a plaque collected (3) Patients for whom written consent has been obtained by the individual

Exclusion criteria

Exclusion criteria: (1) Patients taking steroids, autoimmune diseases, undergoing treatment for cancer, or suffering from hepatitis B and C viruses (2) Other patients who are deemed inappropriate by the physician in charge of the study.

Design outcomes

Primary

Measure	Time frame
Cluster analysis of single-cell RNA sequencing and cluster analysis of gene expression variation in each cluster on both stable and unstable coronary atherosclerosis	—

Secondary

Measure	Time frame
Relationship between plaque assessment collected by DCA and various plaque data 1.Plaque evaluation by CT 2.Plaque assessment by cMRI 3. Bulk RNA sequencing 4. microRNA sequencing 5. Histological evaluation	—

Countries

Japan

Contacts

Public ContactHiroyuki Yamamoto

Hyogo Brain and Heart Centor The division of Cardiovascular medicine

y0493589m@hotmail.co.jp079-293-3131

Outcome results