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Prolonged versus Intermittent beta-lactam Antibiotics Intravenous Infusion Strategy in Sepsis or Septic Shock: A Systematic Review and Meta-Analysis of Randomized Trials.

Prolonged versus Intermittent beta-lactam Antibiotics Intravenous Infusion Strategy in Sepsis or Septic Shock: A Systematic Review and Meta-Analysis of Randomized Trials. - Prolonged versus Intermittent beta-lactam Antibiotics Intravenous Infusion Strategy in Sepsis or Septic Shock: A Systematic Review and Meta-Analysis of Randomized Trials.

Status
Active, not recruiting
Phases
Unknown
Study type
Unknown
Source
JPRN
Registry ID
JPRN-UMIN000040688
Enrollment
Unknown
Registered
2020-06-08
Start date
2019-04-27
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sepsis or septic shock

Interventions

None listed

Sponsors

Juntendo University Urayasu Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: We identified studies to be included by following the research question formulated according to the participants, interventions, comparisons and outcomes (PICO) model as follows: P, adult (>=18 years of age) patients admitted to the ICU with a diagnosis of sepsis or septic shock; I, prolonged beta-lactam antibiotics infusion strategy (continuous or extended time [more than 1 hour but not continuous] of intravenous infusion); C, intermittent beta-lactam antibiotics infusion strategy (within 1 hour of intravenous infusion); O, All-cause mortality.

Exclusion criteria

Exclusion criteria: Under 18 years-old

Design outcomes

Primary

MeasureTime frame
hospital mortality—

Secondary

MeasureTime frame
attainment of target plasma concentration, clinical cure, adverse event, and occurrence of antibiotic-resistant bacteria—

Countries

Japan

Contacts

Public ContactYutaka Kondo

Juntendo University Urayasu Hospital Department of Emergency and Critical Care Medicine

kondokondou2000@yahoo.co.jp047-353-3111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026