Difference in clinical features between idiopathic and secondary chronic intestinal pseudo-obstruction:A retrospective single center study

Difference in clinical features between idiopathic and secondary chronic intestinal pseudo-obstruction:A retrospective single center study - Difference in clinical features between idiopathic and secondary chronic intestinal pseudo-obstruction

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000040669

Enrollment

Registered

2020-06-08

Start date

2020-09-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Intestinal Pseudo-obstruction (CIPO)

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients who meet following 1-7 criteria (idiopathic CIPO) or 1-6 criteria (secondary CIPO) are eligible Diagnostic criteria of CIPO 1. Persistent or recurrent symptoms of bowel obstruction such as abdominal bloating, nausea, vomiting, and pain 2. Disease duration of more than 2 months for newborn onset and 6 months for onset after infancy 3. Dilatation of gastrointestinal tract and air-fluid level on radiological images 4. No evidence of structural diseases 5. No morphological abnormalities in the plexus on HE staining of intestinal full-thickness biopsy 6. Exclusion of megacystis microcolon intestinal hypoperistalsis syndrome (MMIHS) and segmental dilatation of intestine for pediatric patients 7. Exclusion of secondary CIPO

Exclusion criteria

Exclusion criteria: 1)Patients with current malignant diseases under treatment (patients with stable condition and not requiring active treatment are allowed) 2)Patients with severe psychiatric diseases (patients with stable condition are allowed)

Design outcomes

Primary

Measure	Time frame
Rate of intravenous hyperalimentation (IVH) requirement	—

Secondary

Measure	Time frame
Ratio of idiopathic and secondary CIPO Underlying diseases in secondary CIPO Age of onset Cine-MRI findings Nutritional status (serum albumin level, body mass index) Effective rate of enteric sterilization Prognosis (Mortality rate)	—

Countries

Japan

Contacts

Public ContactHidenori Ohkubo

Yokohama City University Hospital Division of Hepatology and Gastroenterology

ohkuboh@yokohama-cu.ac.jp045-787-2800

Outcome results