Healthy adults
Conditions
Interventions
Toothbrushing with test toothpaste for 1 week , wash out for 1 week .Toothbrushing with placebo toothpaste for 1 week
Toothbrushing with placebo toothpaste for 1 week , wash out for 1 week . Toothbrus
Sponsors
Nagasaki University Graduate School
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Subjects who are undergoing dental maintenance at Nagasaki University Hospital
Exclusion criteria
Exclusion criteria: Subjects with severe liver and kidney dysfunction Subjects with drug hypersensitivity constitution Subjects who have systemic disease and are being treated at a clinic Subjects with xerostomia Smoker Subjects who took antibiotics within one month Subjects who participated other clinical study within 4 months Female who are pregnant and lactating Subjects deemed inappropriate to participate in this study by the principle investigator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Dental plaque evaluation after a test dentifrice use | — |
Secondary
| Measure | Time frame |
|---|---|
| Intraoral photos after test dentifrice use. Number of bacteria in plaque after test dentifrice use. Amount of LPS in plaque after test dentifrice use. Cytokine induction by plaque after test dentifrice use. Cell stimulation by plaque after test dentifrice use. Inflammation of periodontal tissue | — |
Countries
Japan
Contacts
Public Contactatsutoshi yoshimura
Nagasaki University Graduate School Biomedical Sciences Department of Periodontology and Endodontology Professor
Outcome results
None listed