Low-dose oral immunotherapy for food allergies (buckwheat, fruits, walnuts, cashews, hazelnuts, and macadamia nuts).

Low-dose oral immunotherapy for food allergies (buckwheat, fruits, walnuts, cashews, hazelnuts, and macadamia nuts). - Low-dose oral immunotherapy

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000040531

Enrollment

Registered

2020-05-26

Start date

2015-11-17

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

food allergy

Interventions

1.The target amount of ingestion is defined as 2 g buckwheat noodle, 10 g fruits, and 0.5 g walnuts, cashews, hazelnuts, and macadamia nuts. 2.The subjects are asked to take a small amount of their c

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients who visited our hospital and exhibited objective symptoms based on the oral food challenge with one of the following food products are included in this study; 2 g buckwheat noodle (100 mg buckwheat protein), 5 g fruits, 0.5 g walnuts (75 mg walnut protein), 0.5 g cashews (90 mg cashew protein), 0.5 g hazelnuts (75 mg hazelnut protein), and 0.5 g macadamia nuts (45 mg macadamia nut protein). Objective symptoms were based on the Japanese Society of Allergology anaphylaxis guidelines (Yanagida N. et al. Allergol Int 2016, Ebisawa M. et al. Allergol Int 2017.).

Exclusion criteria

Exclusion criteria: 1.The subject who has poorly treated atopic dermatitis and bronchial asthma. 2.The subject who seems inappropriate candidate for oral immunotherapy as judged by a medical doctor.

Design outcomes

Primary

Measure	Time frame
The rate of short-term unresponsiveness* to the middle-dose** after 1 year * Short-term unresponsiveness is defined as "when patients passed the middle-dose oral food challenge after complete avoidance for 2 weeks." ** The middle-dose is defined as "16 g buckwheat noodle, 40 g fruits, and 3 g walnuts, cashews, hazelnuts, and macadamia nuts."	—

Secondary

Measure	Time frame
1. Frequency of adverse reactions 2. The rate of short-term unresponsiveness* to the middle-dose** after 2 years, 3 years, 4 years, and 5 years from the start of oral immunotherapy(OIT) 3. Changes of specific IgE, IgG, and IgG4 * Short-term unresponsiveness is defined as "when patients passed the middle-dose oral food challenge after complete avoidance for 2 weeks." ** The middle-dose is defined as "16 g buckwheat noodle, 40 g fruits, and 3 g walnuts, cashews, hazelnuts, and macadamia nuts."	—

Measure

Time frame

1. Frequency of adverse reactions 2. The rate of short-term unresponsiveness* to the middle-dose** after 2 years, 3 years, 4 years, and 5 years from the start of oral immunotherapy(OIT) 3. Changes of specific IgE, IgG, and IgG4 * Short-term unresponsiveness is defined as "when patients passed the middle-dose oral food challenge after complete avoidance for 2 weeks." ** The middle-dose is defined as "16 g buckwheat noodle, 40 g fruits, and 3 g walnuts, cashews, hazelnuts, and macadamia nuts."

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Countries

Japan

Contacts

Public ContactNoriyuki Yanagida

National Hospital Organization Sagamihara National Hospital Clinical Research Center for Allergy and Rheumatology

yana@foodallergy.jp042-742-8311

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026