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The effect of high-dose vitamin C in patients with sepsis: A systematic review and meta-analysis of randomized controlled trials

The effect of high-dose vitamin C in patients with sepsis: A systematic review and meta-analysis of randomized controlled trials - The effect of high-dose vitamin C in patients with sepsis

Status
Active, not recruiting
Phases
Unknown
Study type
Unknown
Source
JPRN
Registry ID
JPRN-UMIN000040528
Enrollment
Unknown
Registered
2020-05-26
Start date
2020-05-21
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sepsis

Interventions

None listed

Sponsors

Cleveland Clinic.
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: We included trials with the following characteristics: 1. Study type: RCT. 2. Patient population: Patients aged above or equal to 18 years with sepsis based on any one of Sepsis-1, Sepsis-2, or Sepsis-3 definitions. 3. Intervention: Intravenous high-dose vitamin C (greater than or equal to 1.5g every 6 hours or 25mg/kg every 6 hours) 4. Control: Placebo or no intervention.

Exclusion criteria

Exclusion criteria: We excluded articles that included patients <18 years, published in non-English and are conference proceedings.

Design outcomes

Primary

MeasureTime frame
Short term mortality including 28-day mortality, 30-day mortality, or in-hospital mortality—

Secondary

MeasureTime frame
ICU length of stay Hospital length of stay Duration of vasopressors Delta SOFA at 72-96 hours Ventilator-free days Adverse events Sub-group analysis based on mean/median control SOFA score. Sub-group analysis based on HAT therapy vs. non-HAT therapy.—

Countries

Japan,North America

Contacts

Public ContactRyota Sato

Cleveland Clinic Critical Care Medicine

st051035@gmail.com1-216-296-8700

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026