Comparison of 1L PEG plus ascorbic acid with Linaclotide versus Sennoside for colon cleaning in constipated patients: A single blind, randomized controlled clinical trial.

Comparison of 1L PEG plus ascorbic acid with Linaclotide versus Sennoside for colon cleaning in constipated patients: A single blind, randomized controlled clinical trial. - Efficacy of Linaclotide as an adjuvant for bowel preparation in constipated patients: A single blind, randomized controlled clinical trial.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000040416

Enrollment

526

Registered

2020-05-18

Start date

2020-05-18

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Constipated outpatients who were scheduled colonoscopy

Interventions

We use 0.5 mg of Linaclotide as an adjuvant for bowel preparation on the day prior to the procedure We use 24 mg of Sennoside as an adjuvant for bowel preparation on the day prior to the procedure

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Constipated outpatients who were scheduled colonoscopy. Chronic constipation was diagnosed by Rome 4 criteria.

Exclusion criteria

Exclusion criteria: 1)contraindication to bowel preparation (congestive heart failure, renal insufficiency, liver failure, a life-threatening condition) 2)mechanical bowel obstruction 3)history of colectomy 4)current pregnancy/lactating 5)active inflammatory bowel disease 6)refusal to provide consent

Design outcomes

Primary

Measure	Time frame
Achievement of preparation adequacy and an overall colon cleansing score of 6 or more using Boston bowel preparation scale.	—

Secondary

Measure	Time frame
Boston bowel preparation scale score Side effects or complications Quality of sleep Willingness to repeat the procedure	—

Countries

Japan

Contacts

Public ContactAkira Higashimori

Osaka City University Graduate school of Medicine Department of Gastroenterology

higamo@med.osaka-cu.ac.jp0666453811

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026