Thrombolysis for Acute Wake-Up and Unclear-Onset Strokes With Alteplase at 0.6 mg/kg: multicenter registration survey

Thrombolysis for Acute Wake-Up and Unclear-Onset Strokes With Alteplase at 0.6 mg/kg: multicenter registration survey - THAWS 2

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000040408

Enrollment

Registered

2020-05-16

Start date

2019-10-23

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

acute ischemic stroke

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with stroke symptoms with unknown time of onset Admitted >4.5 hours since last-known-well and within 4.5 hours after symptom recognition. No marked signal change on MRI FLAIR.

Exclusion criteria

Exclusion criteria: Contraindication of IV rt-PA. Contraindication of MRI.

Design outcomes

Primary

Measure	Time frame
symptomatic intracranial hemorrhage within 36 hours after IV rt-PA.	—

Secondary

Measure	Time frame
all-cause death within 90 days after stroke 90-day modified Rankin Scale score of 0-1 all adverse events within 90 days NIHSS at 24h	—

Countries

Japan

Contacts

Public ContactSohei Yoshimura

National Cerebral and Cardiovascular Center Department of Cerebrovascular Medicine

sohei-y@ncvc.go.jp0661701070

Outcome results