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Efficacy and safety of early tranexamic acid administration in traumatic brain injury patients: a systematic review and meta-analysis

Efficacy and safety of early tranexamic acid administration in traumatic brain injury patients: a systematic review and meta-analysis - Efficacy and safety of early tranexamic acid administration in traumatic brain injury patients: a systematic review and meta-analysis

Status
Active, not recruiting
Phases
Unknown
Study type
Unknown
Source
JPRN
Registry ID
JPRN-UMIN000040389
Enrollment
Unknown
Registered
2020-05-13
Start date
2020-05-13
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Traumatic brain injury

Interventions

None listed

Sponsors

Nippon Medical School
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: MEDLINE, the Cochrane Central Register of Controlled Trials, and Igaku Chuo Zasshi (ICHUSHI) Web were searched. Selection criteria included randomized controlled trials with clinical outcomes of adult TBI patients administered TXA or placebo in the early phase after admission.

Exclusion criteria

Exclusion criteria: MEDLINE, the Cochrane Central Register of Controlled Trials, and Igaku Chuo Zasshi (ICHUSHI) Web were searched. Selection criteria included randomized controlled trials with clinical outcomes of adult TBI patients administered TXA or placebo in the early phase after admission.

Design outcomes

Primary

MeasureTime frame
Mortality—

Secondary

MeasureTime frame
good neurological outcome rates, enlargement of bleeding, incidence of ischemia, and hemorrhagic intracranial complications.—

Countries

Japan

Contacts

Public ContactShoji yokobori

Nippon Medical School Department of Emergency and Critical Care Medicine

shoji@nms.ac.jp81338222131

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026