Relationship between structure (retinal ganglion cell and vessel) and function (visual field) in early glaucoma

Relationship between structure and function in early glaucoma - Relationship between structure and function in early glaucoma

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000040372

Enrollment

200

Registered

2020-05-12

Start date

2020-07-10

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Glaucoma patient and Healthy volunteer

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: The participant who did not meet exclusion criteria.

Exclusion criteria

Exclusion criteria: Glaucoma patient (1) Corneal disease, retinal disease, diabetes, severe dry eye, and Emery-Little criteria 3 or higher. (2) Corrected visual acuity less than 0.8. (3) Refractive error exceeds spherical plus or minus 8D or astigmatism plus or minus 2D. (4) Axial length exceeds 26.5 mm. (5) IOP 30 mmHg or more. (6) Fixation loss, false negatives, or false positives of 30% or more in Humphrey 24-2 or 30-2. (7) MD less than -3dB with Humphrey 24-2 or 30-2. (8) History of intraocular surgery other than the usual cataract surgery. (9) The patient who have had refractive surgery including multi-focal IOL. Healthy control (1) Ophthalmic diseases that affect the visual field other than refractive error. (2) Corrected visual acuity less than 0.8 (3) Refraction exceeds spherical power plus or minus 8D or astigmatism plus or minus 2D (4) Axial length exceeds 26.5 mm. (5) IOP 21 mmHg or more (6) Fixation loss, false negatives, or false positives of 30% or more with Humphrey 24-2. (7) Having a visual field abnormality that meets the Anderson criteria on the Humphrey 24-2 (8) History of refractive surgery

Design outcomes

Primary

Measure	Time frame
To determine the proportion of cases that are inconsistent with those that follow the conventional order of abnormal appearance among the Humphrey visual field, Pulsar visual field, retinal ganglion cell thickness, peripapillary nerve fiber layer thickness, and macular and peripapillary retinal perfusion density and then to identify the factors associated with the discrepancy using a logistic multiple regression model.	—

Measure

Time frame

To determine the proportion of cases that are inconsistent with those that follow the conventional order of abnormal appearance among the Humphrey visual field, Pulsar visual field, retinal ganglion cell thickness, peripapillary nerve fiber layer thickness, and macular and peripapillary retinal perfusion density and then to identify the factors associated with the discrepancy using a logistic multiple regression model.

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Countries

Japan

Contacts

Public ContactKazunori Hirasawa

School of Medicine, Kitasato University Department of Ophthalmology

hirasawa@kitasato-u.ac.jp042-778-8464

Outcome results