Healthy control
Conditions
Interventions
Subjective brain response will be examined during rumination task. (2set, 10 min each)
Sponsors
Keio University School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Aged >=20 yrs, <=60yrs 2.Subjects who give full consent in the participation of the study.
Exclusion criteria
Exclusion criteria: 1. No history or concurrent DSM-IV Axis I Disorders. 2. No organic brain lesions or major cognitive deficits in a year prior to the screening. 3. No severe or unstable medical illness at screening. 4. Contraindication to MRI (including cardiac pacemaker, claustrophobia)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Brain functional activity and connectivity and during rumination task recorded by fMRI | — |
Secondary
| Measure | Time frame |
|---|---|
| -Depression symptoms: Beck Depression Inventory, Quick Inventory of Depressive Symptomatology -Anxiety symptoms: Generalized Anxiety Disorder -7 - Hopelessness: Beck Hopelessness Scale -Rumination : Ruminative Response Scale -Aboidance: Cognitive-Behavioral Avoidance Scale -Coping: Coping Inventory for Stressful Situations -Disability: Sheehan Disability Scale -QOL: EuroQol -resting state functional connectivity (resting-fMRI) -Cognition on future-thinking: future-thinking task -Cognitive function: CABTAB or The Brief Assessment of Cognition in Schizophrenia: BACS-J | — |
Countries
Japan
Contacts
Public ContactNariko Katayama
Keio University School of Medicine Department of Neuropsychiatry
Outcome results
None listed