Involvement of esophageal achalasia and achalasia-related diseases and viral infections and their regulators

Involvement of esophageal achalasia and achalasia-related diseases and viral infections and their regulators - Involvement of esophageal achalasia and achalasia-related diseases and viral infections and their regulators

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000040317

Enrollment

210

Registered

2020-05-07

Start date

2024-03-31

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

esophageal achalasia and achalasia-related diseases

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients group: Showa University Koto Toyosu Hospital Gastroenterology Center, Fukuoka University Hospital, Tokyo Jikei University School of Medicine Hospital (1) Patients over 20 years old who undergo POEM treatment for esophageal achalasia and achalasia-related diseases (2) Patients who fully understand this research plan and can consent to it (3) Patients who are 20 years of age or older at the time of obtaining consent Control group: Tottori University Hospital (1) Patients with non-esophageal movement disorders such as esophageal cancer who undergo esophagectomy (2) Patients who fully understand this research plan and can consent to it (3) Patients who are 20 years of age or older at the time of obtaining consent

Exclusion criteria

Exclusion criteria: Patients group: (1) Patients who are judged to be ineligible to perform POEM (2) Patients who are judged to be inappropriate by the doctor in charge (for example, patients in a significantly bad condition) (3) Patients who cannot obtain informed consent Control group: Patients who cannot obtain informed consent

Design outcomes

Primary

Measure	Time frame
Quantitative analysis of herpesvirus microRNA expression in the esophageal muscle layer of patients with esophageal achalasia or achalasia-related disease. Transcriptome analysis of infectious virus species and their regulatory molecules in the esophageal muscle layer of patients with esophageal achalasia or achalasia-related diseases.	—

Secondary

Measure	Time frame
Relationship between esophageal achalasia (Type I, Type II, Type III) or patients with achalasia-related diseases and viral infection in the esophageal muscle layer and its regulatory molecules and various pathological conditions. Relationship between esophageal achalasia (Type I, Type II, Type III) or achalasia-related disease patients, identified virus species, and various pathological conditions. Serological diagnosis of viruses that can cause esophageal achalasia and other esophageal dyskinesia.	—

Measure

Time frame

Relationship between esophageal achalasia (Type I, Type II, Type III) or patients with achalasia-related diseases and viral infection in the esophageal muscle layer and its regulatory molecules and various pathological conditions. Relationship between esophageal achalasia (Type I, Type II, Type III) or achalasia-related disease patients, identified virus species, and various pathological conditions. Serological diagnosis of viruses that can cause esophageal achalasia and other esophageal dyskinesia.

—

Countries

Japan

Contacts

Public ContactYuichiro Ikebuchi

Tottori University Hospital Gastroenterology

ikebu@tottori-u.ac.jp0859-38-6527

Outcome results