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Effects of oral 6-methylsulfinyl hexyl isothiocyanate ingestion on muscle damage after eccentric exercise in healthy males: a pilot placebo-controlled double-blind crossover study

Effects of oral 6-methylsulfinyl hexyl isothiocyanate ingestion on muscle damage after eccentric exercise in healthy males: a pilot placebo-controlled double-blind crossover study - Effects of oral 6-methylsulfinyl hexyl isothiocyanate ingestion on muscle damage after eccentric exercise in healthy males: a pilot placebo-controlled double-blind crossover study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000040273
Enrollment
8
Registered
2020-04-30
Start date
2017-08-14
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy adults

Interventions

Duration: 6 days Test food: 6-MSITC Control food: Starch Washout: 4 weeks Administration: 3 mg 3 times a day, after meals (9 mg/day) 1. Test food 2. wash out period 3. Control food Duration

Sponsors

Japan Institute of Sports Sciences
Lead Sponsor

Eligibility

Sex/Gender
Male

Inclusion criteria

Inclusion criteria: 1. Participants who had no history of musculoskeletal injury or disease 2. Participants who had not engaged in regular resistance training 3. Participants who had not take any supplements and over-the-counter-medications

Exclusion criteria

Exclusion criteria: (1) Participants who had a history or signs of a heart or cerebrovascular disease (2) Participants who had diabetes, a liver, kidney or respiratory disease, endocrine disorder, metabolic disorder, organ disorder, gout, rheumatism, autoimmune disease, allergy disease, mental disorder, cancer, infection disease, or other diseases (3) Participants who had allergic reaction to food (4) Participants who were judged to be inappropriate for the study by the medical doctor or investigator for other reason

Design outcomes

Primary

MeasureTime frame
Maximal voluntary isometric contraction torque before and after eccentric exercise

Secondary

MeasureTime frame
Plasma calpain-1 activity Inflammatory markers Serum creatine kinase activity Urinary titin fragment concentration Muscle soreness Range of motion Transverse relaxation time

Countries

Japan

Contacts

Public ContactHideyuki Takahashi

Japan Institute of Sports Sciences Department of Sports Research

hideyuki.takahashi@jpnsport.go.jp03-5963-0230

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026