Investigation of the mechanism of acquiring oral tolerance and its application to diagnosis/treatment

Investigation of the mechanism of acquiring oral tolerance and its application to diagnosis/treatment - Investigation of the mechanism of acquiring oral tolerance and its application to diagnosis/treatment

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000040176

Enrollment

Registered

2020-04-16

Start date

2020-05-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Food allergy

Interventions

Single-arm study. The intervention is to take certain allergens orally for 3-5 years.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Food allergy patients diagnosed by oral food challenge test. 2) Patients who agreed to participate in this study with written consent. 3) The analysis also includes patient specimens who underwent oral immunotherapy from 2011 to April 2020.

Exclusion criteria

Exclusion criteria: 1) Patients with serious chronic diseases such as malignant tumors or immunodeficiency. 2) Patients who are not eligible for adrenaline self-injection. 3) Patients who the investigator judged to be unsuitable for the study.

Design outcomes

Primary

Measure	Time frame
Unresponsiveness to orally ingested allergens	—

Secondary

Measure	Time frame
Allergen-specific immunoglobulins (IgG4/IgE/IgA), Lymphocyte function	—

Countries

Japan

Contacts

Public ContactMotoko Yasutomi

Faculty of Medical Sciences, University of Fukui Department of Pediatrics

yasutomi@u-fukui.ac.jp0776(61)3111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026