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The effect of esmolol and landiolol on the mortality in patients with sepsis and septic shock with tachycardia: A systematic review and meta-analysis of randomized controlled trials

The effect of esmolol and landiolol on the mortality in patients with sepsis and septic shock with tachycardia: A systematic review and meta-analysis of randomized controlled trials - The effect of esmolol and landiolol on the mortality in patients with sepsis and septic shock with tachycardia: A systematic review and meta-analysis of randomized controlled trials

Status
Active, not recruiting
Phases
Unknown
Study type
Unknown
Source
JPRN
Registry ID
JPRN-UMIN000040174
Enrollment
500
Registered
2020-05-01
Start date
2020-04-15
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sepsis and septic shock

Interventions

None listed

Sponsors

Fujita Health University School of Medicine Anesthesiology and critical care medicine
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Study types: randomized controlled trial (RCT). 2. Population: Patients no less than 18 years old and with sepsis based on any one of sepsis-1, sepsis-2, or sepsis-3 definitions. 3. Intervention: Intravenous esmolol or landiolol administration at any dose. 4. Control: Placebo or no intervention (without esmolol or landiolol administration).

Exclusion criteria

Exclusion criteria: studies not met inclusion criteria

Design outcomes

Primary

MeasureTime frame
Short term mortality (in hospital mortality, 28 day mortality)—

Secondary

MeasureTime frame
White blood cell count, troponin I, BNP, inflammatory marker and so forth Hemodynamic status(heart rate, blood pressure and so on)—

Countries

Japan,North America

Contacts

Public ContactDaisuke Hasegawa

Fujita Health University School of Medicine Anesthesiology and critical care medicine

dhsgw@fujita-hu.ac.jp0562-93-9008

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026