Moyamoya Disease with Aggressive Clinical Course in Infants for Safety and Healthy Growth Study

Moyamoya Disease with Aggressive Clinical Course in Infants for Safety and Healthy Growth Study - MACINTOSH Study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000040169

Enrollment

100

Registered

2020-04-15

Start date

2021-03-31

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

moyamoya disease

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) younger than 4 years old 2) onset between Jan 2008 and December 2018 3) radiologically confirmed moyamoya disease 4) patients with disease progression, recurrence of cerebrovascular events, or perioperative complications 5) Informed consent was obtained

Exclusion criteria

Exclusion criteria: 1) informed consent was not obtained 2) doctor-in-charge did not accept the enrollment

Design outcomes

Primary

Measure	Time frame
Incidence of following events in infantile moyamoya disease (<4 years old) 1) stroke before bypass surgery 2) disease progression 3) perioperative complications 4) repeat bypass for ACA/PCA area 5) any death 6) poor functional outcome (mRS=3-5) 7) poor intellectual outcome (FSIQ<60)	—

Secondary

Measure	Time frame
Incidence of flooding events in infantile moyamoya disease (<4 years old) 1) anti platelet 2) postoperative anemia 3) disease stage and moyamoya vessels at the onset 4) cerebral infarct at the onset 5) increase of cerebral infarct during follow-up period	—

Countries

Japan

Contacts

Public ContactSatoshi Kuroda

University of Toyama Department of Neurosurgery

skuroda@med.u-toyama.ac.jp+81-76-434-7348

Outcome results