A study of the association of dopamine D1 and D2 receptor binding potentials in the brain with clinical features of patients with dystonia

A study of the association of dopamine D1 and D2 receptor binding potentials in the brain with clinical features of patients with dystonia - A study of the association of dopamine D1 and D2 receptor binding potentials in the brain with clinical features of patients with dystonia

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000040130

Enrollment

Registered

2020-04-20

Start date

2020-04-21

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

dystonia

Interventions

PET/MRI/psychological batteries/neurological examinations PET/MRI/psychological batteries/neurological examinations

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) patients with dystonia 1. 17 years of age or older at the time of obtaining consent 2. patients with dystonia or carriers who have DYT-T gene abnormalities 2) Healthy volunteers Healthy volunteers who underwent PET scans with 11C-SCH23390 or 11C-raclopride in the 17-005 Study, the 11-023 Study, the 12-003 Study, and the 12-008 Study conducted at National Institutes for Quantum and Radiological Science and Technology and have not refused secondary use of their data at the time of obtaining consent

Exclusion criteria

Exclusion criteria: 1) patients with dystonia 1. Subjects with organic brain complications/disorders 2. Subjects with substance-related disorders 3. Subjects with severe physical complications/disorders or a history of such conditions 4. Subjects with claustrophobia 5. Pregnant, possibly pregnant or lactating women 6. From the standpoint of radiation exposure from a nuclear medicine scan, subjects who have participated in other nuclear medicine scans as healthy volunteers in the 6 months prior to the start of this study 7. Subjects who are considered to be inappropriate for participation by doctors with responsibilities in this study 2) Healthy volunteers We exclude the data of the healthy volunteers who refused secondary use of their data for another clinical studies at the time of obtaining consent. Under the announcement of the secondary use in the homepage of National Institutes for Quantum and Radiological Science and Technology, we exclude the data of the healthy volunteers who underwent scans or examinations in the studies by 31 December 2019, if they refuse secondary use by 30 June 2020.

Design outcomes

Primary

Measure	Time frame
The associations between dopamine D1 and D2 receptor binding potentials evaluated by PET and clinical features of dystonia	—

Secondary

Measure	Time frame
The associations between dopamine D1 and D2 receptor binding potentials evaluated by PET and brain structures evaluated by MRI of dystonia	—

Countries

Japan

Contacts

Public ContactKazuko Suzuki

National Institutes for Quantum and Radiological Science and Technology Clinical Research Support Section, National Institute of Radiological Sciences

suzuki.kazuko@qst.go.jp+81-43-206-3251

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026