Mood disorder
Conditions
Interventions
A physical exercise intervention for 8 weeks will be given to the subjects in the exercise group. There are no restrictions on drug or psychotherapy treatments. The physical exercise intervention cons
anaerobic metabolic threshold (AT: exercise intensity at which oxygen cannot be supplied to muscles) calculated based on the cardiopulmonary exercise testing (CPX). Meanwhile, the intensity of the cyc
perceived exertion stay no higher than 13 (somewhat hard) as evaluated by the Borg Rating of Perceived Exertion Scale. Each session is then finalized by a 10-minute cool-down stretching exercise. At t
Sponsors
Division of Neuropsychiatry, Department of Neuroscience, Yamaguchi University Graduate School of Medicine
Department of Biostatistics, Yamaguchi University Graduate School of Medicine Department of Radiology, Yamaguchi University Graduate School of Medicine Faculty of Health Sciences, Yamaguchi University Graduate School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Patients diagnosed as "Depressive Disorders" or "Bipolar and Related Disorders" according to the Diagnostic and Statistical Manual of Mental Disorders, 5th ed. (DSM-5). Patients in the "Depressive Disorders" are restricted to those who have used one or more antidepressants but have not achieved remission (Hamilton Depression Rating Scale (HAM-D) 17-item version score is greater than or equal to 8). 2) Those who are at least 20 years old and under 61 years old at the time of obtaining consent. 3) Irrespective of gender. 4) Patients who are able to provide a written informed consent after being explained the details of the study.
Exclusion criteria
Exclusion criteria: 1) Strong suicidal thoughts. 2) Patients who score five or more on the Young Manic Rating Scale (YMRS). 3) Patients with active inflammatory disease. 4) Patients with malignant tumor. 5) Patients who cannot exercise, for example, due to orthopedic disease or body weight exceeding the allowance of the ergometer. 6) Patients who have already been performing regular physical exercise. 7) Others subjects who are considered inappropriate for this study (e.g., being pregnant or possibly pregnant).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Depressive symptoms evaluated at the beginning and after eight weeks of the intervention by the Structured Interview Guide for the Hamilton Depression Rating Scale (SIGH-D) | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) Self-report depressive symptoms evaluated by BDI-II 2) Other mental status evaluations (including anxiety, social adaptation, and psychological wellbeing), and neuropsychiatric tests (including working memory, reinforcement learning, and creativity), etc. | — |
Countries
Japan
Contacts
Public ContactChong Chen
Yamaguchi University Graduate School of Medicine Division of Neuropsychiatry, Department of Neuroscience
Outcome results
None listed