A multi-institutional prospective observational study of LINAC-based single isocenter stereotactic irradiation for multiple brain metastases

A multi-institutional prospective observational study of LINAC-based single isocenter stereotactic irradiation for multiple brain metastases - SISTI study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000040093

Enrollment

Registered

2020-04-07

Start date

2020-04-07

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

brain metastases

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1)20 years old or higher 2)Diagnosed as solid malignant tumors (except small-cell lung cancer and malignant lymphoma) 3)2 or more brain metastases as counted on a gadolinium contrast-enhanced MRI (maximum 10 brain metastases) 4)The longest diameter of each gross tumor volume (GTV) is smaller than 3 cm, and each GTV is smaller than 10 cm3. Total volume of all GTV is smaller than 15 cm3. 5)Performance status 0-2 or 3 (only if caused by the tumor) 6)No leptomeningeal metastases 7)No previous surgery or irradiation to the skull or brain.

Exclusion criteria

Exclusion criteria: 1)With severe coexisting diseases such as collagen disease, heart disease, respiratory disease and liver disease. 2)Psychotic disease 3)Contraindications for MRI examination with gadolinium agent use

Design outcomes

Primary

Measure	Time frame
Local control rate at 6 months after LINAC-based single isocenter stereotactic irradiation per case	—

Countries

Japan

Contacts

Public ContactTakashi Mizowaki

Kyoto University Graduate School of Medicine Department of Radiation Oncology and Image-applied Therapy

mizo@kuhp.kyoto-u.ac.jp075-751-3417

Outcome results