Autism Spectrum Disorder
Conditions
Interventions
Rumination Focused Cognitive Behavioral Therapy (RFCBT) including every week 12 one-hour sessions and treatment as usual
Treatment as usual
Sponsors
Hamamatsu University School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Those who are 18 years old or older and under 50 years old at the time of obtaining consent. 2) Diagnosis of autism spectrum disorder based on Diagnostic and Statistical Manual of Mental Disorders-V(DSM-5)with score exceeding the cut-off value of Autism Diagnostic Observation Schedule Second Edition(ADOS-2)or Autism Diagnostic Interview-Revised(ADI-R). 3) Full Intelligent quotient above 80. 4) Hamilton Depression Rating Scale:(HDRS)score as 8 or more. 5) Applicants who have been given sufficient explanations to participate in this study and who have given their full understanding and consent in writing by themselves or their sponsors.
Exclusion criteria
Exclusion criteria: 1) Those who have a high urgency for treatment, such as an imminent suicide attempt. 2) Patients with intracranial occupational lesions or vascular lesions such as cerebral infarction. 3) Patients with neurological diseases such as epilepsy. 4) MRI contraindicated. 5) Pregnancy or possible pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in the Hamilton Depression Rating Scale (HDRS) 17-item version between baseline and endpoint. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Resting state functional Magnetic Resonance Image(rs-fMRI) 2. Magnetic Resonance Image structure imag:T1- and T2-weighted images 3. Proton magnetic resonance spectroscopy(1H-MRS) 4. Beck Depression Inventory(BDI) 5. Ruminative Responses Scale(RRS) 6. State-Trait Anxiety Inventory(STAI) 7. Autism Spectrum Quotient-Japan(AQ-J) 8. Repetitive Behavior Scale-Revised(RBS-R) | — |
Countries
Japan
Contacts
Public ContactShun Takeichi
Hamamatsu University School of Medicine Department of Psychiatry
Outcome results
None listed