Myelomeningocele
Conditions
Interventions
Sponsors
OSAKA University Department of Medicine Division of Obstetrics and Gynecology
National Center for Child Health and Development
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: Myelomeningocele at level T1 through S1 With evidence of hindbrain herniation at least 20 years old of maternal age 19+0 to 25+6 weeks of gestational age Singleton pregnancy
Exclusion criteria
Exclusion criteria: Additional fetal anomalies not related with MMC HIV or Hepatitis B/C positive Increased risk for preterm delivery: short cervix, cervical incompetency, uterine anomaly, previa, prior spontaneous preterm delivery Multifetal pregnancy Previous hysterotomy Prior abruptio placentae Kyphosis in the fetus of 30 degrees or more Insulin dependent pregestational diabetes Rh isoimmunization Body mass index > 35 Patient does not have a support person. Psychosocial issues preventing compliance Other contraindications to elective surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hindbrain herniation at the age of 12 months | — |
Secondary
| Measure | Time frame |
|---|---|
| the need for placement of a cerebrospinal fluid shunt by the age of 12 months Accomplishments of the fetal surgery Maternal Adverse Events Fetal Adverse Events | — |
Countries
Japan
Contacts
Public ContactMASAYUKI ENDO
Osaka University Division of Medicine, Obstetrics and Gynecology
Outcome results
None listed