N/A(healthy adults)
Conditions
Interventions
Duration: 8 weeks Test material: Food containing carrot concentrate Dose: Two times a day Administration: Take test material before breakfast and dinner
Sponsors
Kyoto Prefectural University Of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Those who agree in writing to participate in this study. 2) Women and men aged 20 to 65 years. 3) Those who can observe the following lifestyle during the test period from one week before the start of the trial. > Do not drink green tea more than usual before starting the trial. > Do not eat foods with high polyphenol content such as chocolate. > Do not take antibiotics. > Do not use mouthwash. > Abstain from taking probiotics (mainly yogurt). > Do not eat natto more than usual before starting the trial. > No smoking. > Do not take prebiotics (dietary fiber and oligosaccharide supplements).
Exclusion criteria
Exclusion criteria: 1) Those who are under treatment of diseases (Digestive disorders) which may influence the outcome of the study. 2) Whose diet is extremely irregular 3) Those who are routinely drinking a large amount of alcohol. 4) Smokers 5) Those who are habitually exercising such as marathon. 6) Currently, exercise therapy and diet therapy are performed/ planning to under the supervision of a physician. 7) Serious heart disease [heart failure, myocardial infarction, myocarditis, etc.] ,liver disease [liver failure symptoms (fulminant hepatitis ),patients with cirrhosis of the liver, liver tumor], renal disease [nephrotic syndrome, renal failure (acute and chronic), uremia, merged, etc. hydronephrosis], cranial nerve disease, psychiatric disease, malignant tumor disease, etc. and have a problem with general condition. 8) Those who have participated in other clinical trials within before consent get one month,and those who are currently participating in other clinical trials. 9) At the physician's judgment, who it is determined that there is a possibility that either increased risk to the subject, or sufficient data not obtained.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| gut microbiota(variety and ratio of bacteria in stool) | — |
Secondary
| Measure | Time frame |
|---|---|
| Defecation status (fecal properties, number of defecations), Bile acids and short-chain fatty acids in feces, Blood carotenoid concentration, Oxidative stress markers, Oxidation-modified transthyretin, Skin condition and fatigue level | — |
Countries
Japan
Contacts
Public ContactTomohisa Takagi
Kyoto Prefectural University of Medicine Department of Gastroenterology and Hepatology
Outcome results
None listed