The modulation of endogenous pain inhibitory mechanism by acetaminophen

The modulation of endogenous pain inhibitory mechanism by acetaminophen - The modulation of endogenous pain inhibitory mechanism by acetaminophen

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000039906

Enrollment

Registered

2020-03-23

Start date

2020-03-23

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

healthy volunteers

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: after informed consent is obtained, over 20 years old

Exclusion criteria

Exclusion criteria: the inability to give informed consent, under 20 years old

Design outcomes

Primary

Measure	Time frame
The evaluation of CPM effect before and after taking acetaminophen. CPM effect is evaluated by pressure pain threshold (PPT) before and during conditioning stimulus.	—

Secondary

Measure	Time frame
the modulation of QST (the Thermal Pain Illusion(TPI), Temporal Summation(TS), Offset Analgesia(OA) etc) and the effect of background (for example, psychology test including SDS, STAI, PCS etc), and the stress evaluated by catecholamine concentrations in plasma, urine and sweat.	—

Countries

Japan

Contacts

Public ContactYuka Oono

Department of Diagnostic and Therapeutic Sciences, School of Dentistry, Meikai University Division of Dental Anesthesiology

yoono@dent.meikai.ac.jp049-279-2738

Outcome results