Major cognitive disorders
Conditions
Interventions
Sponsors
Yokohama City University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.40 years old older and younger than 100 years old at the registration. 2.Patients diagnosed with AD or DLB or FTD or P SP or CBS or MCI. 3.Patients who can express intents to participate in this research with written documents on their own or by substitutes. 4.Patients who can visit Yokohama City University Hospital with their caregiver.
Exclusion criteria
Exclusion criteria: 1.Patients who can not be performed head MRI due to their implanted metals, claustrophobia, tattoo or art makeup. 2.Patients who have a alcohol hypersensitivity. 3.Patients who have a history or a plan of brain surgery. 4.Patients pointed out neurological disorders independent of major cognitive disorders or MCI. 5.Patients who have a plan of RI examination 72 hours before AMPA PET imaging.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| SUVR and BPND,which reference domains are white matter, in each diagnostic category in atrophic cortex. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.The basic statistics(BS) of neuropsychological tests(NPT) in each category. 2.The BS of MDS-UPDRS Part 3 in each category.3.The BS of MDS-UPDRS Part 1 and 2 in DLB, PSP and CBS.4.The BS of SUVRs in each category in each defined brain region(DBR). 5.The BS of BPNDs, which reference domain is white matter, in each category in each DBR. 6.The results of NPT and SUVRs in each category and in whole subjects in each DBR. 7.The disease durations and SUVRs in each category and in whole subjects in each DBR. 8.The results of NPT and BPNDs in each category and in whole subjects in each DBR. 9.The disease durations and BPNDs in each category and in whole subjects in each DBR. 10.PSPRS and SUVRs in PSP groups in each defined brain region. 11.PSPRS and BPNDs in PSP groups in each defined brain region. 12.MDS-UPDRS Part 3 and SUVRs in each category and in whole subjects in each DBR. 13.MDS-UPDRS Part 3 and BPNDs in each category and in whole subjects in each DBR. 14.MDS-UPDRS Part 1 and 2 and SUVRs in DLB, PSP and CBS and in the whole subjects in the groups in each DBR. 15.MDS-UPDRS Part 1 and 2 and BPNDs in DLB, PSP and CBS and in the whole subjects in the groups in each DBR. 16.SUVRs computed in voxels clustered and the results of NPT in each category and in whole subjects. 17.BPNDs computed in voxels clustered and the results of NPT in each category and in whole subjects. 18.SUVRs computed in voxels clustered and PSPRS in PSP groups. 19.BPNDs computed in voxels clustered and PSPRS in PSP groups. 20.SUVRs computed in voxels clustered and MDS-UPDRS Part 3 in each category and in whole subjects. 21.BPNDs computed in voxels clustered and MDS-UPDRS Part 3 in each category and in whole subjects, 22.SUVRs computed in voxels clustered and MDS-UPDRS Part 1 and 2 in DLB, PSP and CBS and in the whole subjects in the groups. 23.BPNDs computed in voxels clustered and MDS-UPDRS Part 1 and 2 in DLB, PSP and CBS and in the whole subjects in the groups. | — |
Countries
Japan
Contacts
Public ContactHiroki Abe
Yokohama City University Graduate School of Medicine Department of Physiology
Outcome results
None listed