Comparing three drugs for reducing heart rate and blood pressure during laryngoscopy andintubation

Comparative study of iv esmolol,iv diltiazem, and iv lignocaine hydrochloride in attenuating pressure response to laryngoscopy and intubation - Comparative study of iv esmolol,iv diltiazem, and iv lignocaine hydrochloride in attenuating pressure response to laryngoscopy and intubation

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000039872

Enrollment

220

Registered

2020-03-20

Start date

2017-12-12

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

55 ASA I/II patients will receive injection Lignocaine 1.5mg/kg iv given 90 seconds before laryngoscopy 55 ASA I/II patients will receive injection esmolol 2mg/kg iv given 3 minutes before laryngos

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: \x41\x67\x65\x20\x67\x72\x65\x61\x74\x65\x72\x20\x74\x68\x61\x6E\x20\x31\x38\x20\x79\x65\x61\x72\x73\x20\x20\x61\x6E\x64\x20\x65\x71\x75\x61\x6C\x20\x6F\x72\x20\x6C\x65\x73\x73\x65\x72\x20\x74\x68\x61\x6E\x20\x20\x36\x30\x20\x79\x65\x61\x72\x73\x20\x6F\x66\x20\x61\x67\x65\x3B\x20\x77\x65\x69\x67\x68\x74\x20\x65\x71\x75\x61\x6C\x20\x74\x6F\x20\x6F\x72\x20\x67\x72\x65\x61\x74\x65\x72\x20\x74\x68\x61\x6E\x20\x34\x30\x6B\x67\x20\x61\x6E\x64\x20\x65\x71\x75\x61\x6C\x20\x6F\x72\x20\x6C\x65\x73\x73\x65\x72\x20\x74\x68\x61\x6E\x20\x39\x30\x20\x6B\x67\x73\x20\x6F\x66\x20\x65\x69\x74\x68\x65\x72\x20\x73\x65\x78\x20\x20\x61\x6E\x64\x20\x42\x4D\x49\x20\x65\x71\x75\x61\x6C\x20\x74\x6F\x20\x6F\x72\x20\x67\x72\x65\x61\x74\x65\x72\x20\x74\x68\x61\x6E\x20\x31\x38\x2E\x35\x20\x20\x61\x6E\x64\x20\x65\x71\x75\x61\x6C\x20\x6F\x72\x20\x6C\x65\x73\x73\x65\x72\x20\x74\x68\x61\x6E\x20\x32\x34\x2E\x39\x20\x6F\x66\x20\x65\x69\x74\x68\x65\x72\x20\x73\x65\x78\x20\x41\x53\x41\x20\x70\x68\x79\x73\x69\x63\x61\x6C\x20\x73\x74\x61\x74\x75\x73\x20\xE2\x80\x93\x20\x0A\x47\x72\x61\x64\x65\x20\x49\x20\x61\x6E\x64\x20\x49\x49\x3B\x50\x61\x74\x69\x65\x6E\x74\x73\x20\x72\x65\x71\x75\x69\x72\x69\x6E\x67\x20\x67\x65\x6E\x65\x72\x61\x6C\x20\x41\x6E\x65\x73\x74\x68\x65\x73\x69\x61\x20\x61\x6E\x64\x20\x45\x6E\x64\x6F\x74\x72\x61\x63\x68\x65\x61\x6C\x20\x49\x6E\x74\x75\x62\x61\x74\x69\x6F\x6E\x2E

Exclusion criteria

Exclusion criteria: \x50\x61\x74\x69\x65\x6E\x74\x20\x2F\x20\x67\x75\x61\x72\x64\x69\x61\x6E\x20\x72\x65\x66\x75\x73\x61\x6C\x20\x66\x6F\x72\x20\x63\x6F\x6E\x73\x65\x6E\x74\x3B\x41\x53\x41\x20\x67\x72\x61\x64\x65\x20\x49\x49\x49\x20\x61\x6E\x64\x20\x49\x56\x3B\x45\x6D\x65\x72\x67\x65\x6E\x63\x79\x20\x73\x75\x72\x67\x65\x72\x69\x65\x73\x3B\x50\x61\x74\x69\x65\x6E\x74\x73\x20\x62\x65\x74\x77\x65\x65\x6E\x20\x61\x67\x65\x20\x67\x72\x65\x61\x74\x65\x72\x20\x74\x68\x61\x6E\x20\x36\x30\x20\x79\x65\x61\x72\x73\x20\x61\x6E\x64\x20\x41\x67\x65\x20\x6C\x65\x73\x73\x65\x72\x20\x74\x68\x61\x6E\x20\x31\x38\x20\x79\x65\x61\x72\x73\x3B\x50\x61\x74\x69\x65\x6E\x74\x73\x20\x77\x65\x69\x67\x68\x69\x6E\x67\x20\x67\x72\x65\x61\x74\x65\x72\x20\x74\x68\x61\x6E\x20\x39\x30\x6B\x67\x20\x61\x6E\x64\x20\x6C\x65\x73\x73\x65\x72\x20\x74\x68\x61\x6E\x20\x34\x30\x6B\x67\x20\x20\x61\x6E\x64\x20\x42\x4D\x49\x20\x6C\x65\x73\x73\x65\x72\x20\x74\x68\x61\x6E\x20\x31\x38\x2E\x35\x20\x61\x6E\x64\x20\x20\x67\x72\x65\x61\x74\x65\x72\x20\x74\x68\x61\x6E\x20\x32\x34\x2E\x39\x3B\x50\x61\x74\x69\x65\x6E\x74\x73\x20\x73\x75\x73\x70\x65\x63\x74\x65\x64\x20\x74\x6F\x20\x68\x61\x76\x65\x20\x64\x69\x66\x66\x69\x63\x75\x6C\x74\x20\x74\x72\x61\x63\x68\x65\x61\x6C\x20\x69\x6E\x74\x75\x62\x61\x74\x69\x6F\x6E\x3B

Design outcomes

Primary

Measure	Time frame
Expected to find the attenuation of hemodynamic changes in patients to laryngoscopy and tracheal intubation using intravenous esmolol, lidocaine, and diltiazem and observed at baseline, after drug administration, immediately after intubation, and at 1, 3, and 5 min after intubation.	—

Secondary

Measure	Time frame
Expected to ascertain the superiority of one drug over the other in suppressing sympathetic response to laryngoscopy and tracheal intubation.	—

Countries

Asia(except Japan)

Contacts

Public ContactSathya Narayanan K

Government medical college,Haldwani Department of anaesthesiology ,criticcal care , pain & palliative medicine

sathyavaan4444@gmail.com+919597447444

Outcome results