A multicenter randomized controlled trial on the efficacy of trans arterial cooling infusion with endovascular therapy for acute ischemic stroke

A multicenter randomized controlled trial on the efficacy of trans arterial cooling infusion with endovascular therapy for acute ischemic stroke - A multicenter randomized controlled trial on the efficacy of trans arterial cooling infusion with endovascular therapy for acute ischemic stroke

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000039851

Enrollment

120

Registered

2020-03-18

Start date

2019-04-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

acute ischemic stroke

Interventions

Just after recanalization, we infuse cool saline from guiding catheter to Internal Carotid Artery. Just after recanalization, we infuse warm saline from guiding catheter to Internal Carotid Artery.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients are eligible to be included in this study, who are more than 18 years old, symptomatic (NIHSS more than 2), confirmed large vessel occlusion of anterior circulation (ICA, MCAM1-2), no large infarct (DWI-ASPECTS more than 5 ), can be punctured within 8 hours from onset, get recanalization (TICI grade more than 2a) and be taken informed consent.

Exclusion criteria

Exclusion criteria: Patients are excluded in this study, who are allergic to contrast agents, have a history of arterial puncture for which compression bleeding is difficult, have severe kidney damage, are latating and pregnant, whose life expectancy is expected to be within 90 days, and are judged inappropriate by doctor.

Design outcomes

Primary

Measure	Time frame
modified Rankin scale 0-2 at 90 days after onset of acute ischemic stroke	—

Countries

Japan

Contacts

Public ContactAkihito Kutsuna

Nippon Medical School Hospital departmento of neurology

kucchan-23@nms.ac.jp03-3822-2131

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026