Analysis of brain activities and behavior prior to and following Deep Brain Stimulation for severe Tourette syndrome

Analysis of brain activities and behavior for assessment of decision-making function prior to and following Deep Brain Stimulation for severe Tourette syndrome - Analysis of brain activities and behavior for assessment of decision-making function prior to and following Deep Brain Stimulation for severe Tourette syndrome

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000039780

Enrollment

Registered

2020-03-12

Start date

2020-02-10

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Severe Tourette syndrome

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients meet the approved study (approved number 2017M098) criteria. The operation criteria are following, 1.Patients with Dystonic tic who are to undergo DBS covered by national Health Care Insurance System 2.Patients over 12 years old. If patients under 12 years old are applicable to the surgery of severe involuntary movement, medical ethical committee will deliberate it. 3.Patients signed an informed consent document. 4.Patient's legal representatives sign an informed consent document if patients are minor. 5.Patients meet DSM-4 for clinical diagnose criteria of Tourette syndrome 6.Patients with severe involuntary movements over 35/50 points on YGTSS in principle. If a patient is life-threatening condition or has difficulty living by involuntary movements even though YGTSS score or treatment period don't meet the inclusion criteria, several clinical departments should discuss carefully and consider the patient's applicability to the surgery 7.More than minimum 6-month medication or psychological therapy failed to improve the symptoms or those were intolerant because of side effects. 8.Multiple departments including with psychiatry, neurosurgery, neurology and pediatrics departments (if the patient is a child) should discuss indication of surgery.

Exclusion criteria

Exclusion criteria: 1.High risk patients with physical or mental complications (severe cardiovascular disorder, severe respiratory dysfunction, severe blood diseases, epilepsy, medical history of severe head injuries, severe stroke, severe neurodegenerative diseases, autism, schizophrenic, manic depression, drug addictions, pregnant, breast-feeding , female patients of child-bearing potential) 2.Patients ineligible to the study based on investigator's decision.

Design outcomes

Primary

Measure	Time frame
Resting state functional MRI	—

Secondary

Measure	Time frame
Neuropsycological assessment data	—

Countries

Japan

Contacts

Public ContactTakashi Morishita

Fukuoka University Hospital Department of Neurosurgery

tmorishita@fukuoka-u.ac.jp092-801-1011

Outcome results