Central pain modulation and exercise-induced hypoalgesia in Japanese patients with osteoarthritis.

Central pain modulation and exercise-induced hypoalgesia in Japanese patients with osteoarthritis. - Central pain modulation in osteoarthritis patients.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000039723

Enrollment

Registered

2020-03-06

Start date

2019-11-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee and hip osteoarthritis

Interventions

Behavioral graded activity

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Female sex Age over 50 years Radiographically confirmed knee osteoarthritis (KOA): Kellgren Lawrence (KL) grade 2 or higher Persistent knee pain for more than 6 months Non-response despite a 3-month guideline-concordant exercise program

Exclusion criteria

Exclusion criteria: Systemic inflammatory diseases (e.g., rheumatoid arthritis) Cognitive impairment Severe medical comorbidities (e.g., neurological disorders; neuropsychiatric disorders such as depression or autism; cardiovascular diseases; cancer) Serious hip or ankle pathology (e.g., osteoarthritis; unhealed fractures) Leg pain referred from the lumbar spine Previous joint replacement Use of centrally acting medications (e.g., antidepressants; anxiolytics)

Design outcomes

Primary

Measure	Time frame
1) Subjective pain, 2) Quantitative sensory testing	—

Secondary

Measure	Time frame
Physical function	—

Countries

Japan

Contacts

Public ContactTakako Matsubara

Kobe Gakuin University Graduate School of Rehabilitation

matsubar@reha.kobegakuin.ac.jp(078)974-1551

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026