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Investigation for the association between complications of diabetes mellitus and corneal nerve fibers visualized by confocal microscopy

Investigation for the association between complications of diabetes mellitus and corneal nerve fibers visualized by confocal microscopy - Investigation for the association between complications of diabetes mellitus and corneal nerve fibers visualized by confocal microscopy

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000039614
Enrollment
250
Registered
2020-02-27
Start date
2020-02-27
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

type 2 diabetes mellitus

Interventions

The following tests are performed on all subjects in the same manner. Tear test (Schirmer test, tear film breakage time) Blood test items: fasting blood glucose, fasting C peptide, HbA1c, serum crea

Sponsors

Hiroshima University Hospital, Department of Ophthalmology
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Patients who are at least 20 years old at the time of consent. Patients who obtain written consent for participation in this study.

Exclusion criteria

Exclusion criteria: Patients with a history of ophthalmic surgery. Patients with type 1 diabetes. Patients who have or have a history of keratoconjunctival disease unrelated to diabetes. Patients who have a history of or are currently suffering from a systemic disease other than diabetes that is expected to affect the cornea. Patients who have a history of or are currently suffering from a neurological disorder other than diabetic neuropathy. Patients who have or have a history of renal disease other than diabetic kidney disease. Patients with a history of cervical and spine surgery. Other patients who are deemed unsuitable for conducting the study by the principal or investigator

Design outcomes

Primary

MeasureTime frame
morphological alternation of corneal nerve fibers, severity of diabetic kidney disease, severity of diabetic neuropathy

Countries

Japan

Contacts

Public ContactKoichiro Shinji

Hiroshima University Hospital Department of Ophthalmology

shinjiko@hiroshima-u.ac.jp082-257-5247

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026