Skin pigmentation induced by UV-irradiation
Conditions
Interventions
12 weeks chronic administration of placebo tablets
12 weeks AP low-dose group (apple polyphenol 300 mg) per day
12 weeks AP high-dose group (apple polyphenol 600 mg) per day
Sponsors
Others/Dermis Research Center
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 20 and 39 years, and with skin phototype-II and -III
Exclusion criteria
Exclusion criteria: 1)anti-oxidative products and supplements including vitamin c, CoQ10, polyphenol extracts such as grape seeds and green tea 2)subjects with skin trouble including atopic dermatitis and foods allergy 3)subjects with serious diseases such as diabetes, liver disease, kidney disease, heart disease 4)subjects with a medical condition requiring active management 5)subjects who wish to become pregnant during lactation, pregnancy or during the study period 6)subjects with irregular menstruation, those whose skin condition changes dramatically due to menstruation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| erythema value, L value, melanin value, transepidermal water loss, moisture, questionnaire | — |
Countries
Japan
Contacts
Public ContactShoji Toshihiko
Asahi Breweries Co Ltd Fundamental Research Laboratory
Outcome results
None listed