Can pupil diameter changes predict individual variability of opioid sensitivity?

Evaluation of the method to predict perioperative opioid requirement by pupillometry before anesthesia and surgery. - Perioperative opioid requirement and pupillometry

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000039582

Enrollment

Registered

2020-03-01

Start date

2020-03-14

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients undergoing laparoscopic hysterectomy

Interventions

We measure the pupil diameter before and after small dose of fentanyl just before induction of general anesthesia. We adjust the doses of propofol and remifentanyl to maintain BIS value, blood pressu

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Patients undergoing laparoscopic hysterectomy

Exclusion criteria

Exclusion criteria: Patients receiving regional anesthesia, taking opioids, having contraindication for drugs planned to use. Patients with diabetes mellitus, psychotic and neurological diseases. Patients taking beta blocking agents, anti-cholinergic agents, and anti-psychotic drugs.

Design outcomes

Primary

Measure	Time frame
Association between the percent decrease in the pupil diameter following a small dose of fentanyl and remifentany consumption during surgery (normalized with ideal body weight and duration of anesthesia). Association between the percent decrease in pupil diameter following a small dose of fentanyl and postoperative fentanyl consumption within 24 h after surgery (normalized with body weight).	—

Countries

Japan

Contacts

Public ContactTomio Andoh

Mizonokuchi Hospital, Teikyo University School of Medicine Department of Anesthesiology

psdelico06@yahoo.co.jp0448443333

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026