Healthy adults
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. Female aged over 20 years and less than 60 years when informed consent. 2. Subjects who show understanding of the clinical study procedures and agreement with participating the study by written informed consent prior to the study.
Exclusion criteria
Exclusion criteria: 1. Subjects who have smoking habit. 2. Subjects who are cold-sensitive constitution. (including subjects like that who feel cold on their hands and foots even in summer) 3. Subjects who are receiving medication due to treatment of disease. 4. In a past month, subjects who have had custom of taking or applying medicine for the treatment of diseases. (Except for cold but include for pollen allergy.) 5. Subjects who have previous and/or current medical history of serious disease in liver, kidney, heart, lung and/or blood. 6. Pregnant or expected pregnant, or lactating women. 7. Subjects who have symptom of dermatologic disease such as atopic dermatitis. 8. Subjects who have undergone surgery on investigation objective portion within the past 6 months. 9. Subjects who are participating the other clinical tests. Subjects who participated within a month prior to the current study and/or who plan to participate the other clinical tests. 10. Other who is determined ineligible by investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| *Measuring blood flow of face *Brown stains and/or red parts by shooting face image (front, right and left). | — |
Secondary
| Measure | Time frame |
|---|---|
| *Vas questionnaire *Chromogranin A in saliva *Oxytocin *Shape change of face image by visually confirmation | — |
Countries
Japan
Contacts
University of Tsukuba, School of Integrative Global Majors