Effect of combined training and detraining on basal BDNF levels and depression index in type 2 diabetic women with depression

Effect of combined aerobic- resistance training and subsequent detraining on brain-derived neurotrophic factor (BDNF) and depression in women with type 2 diabetes mellitus: a randomized controlled trial - Effect of aerobic- resistance training and subsequent detraining on brain-derived neurotrophic factor and depression in women with type 2 diabetes

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000039519

Enrollment

Registered

2020-02-18

Start date

2020-02-27

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

type 2 diabetic women with depression

Interventions

Moderate intensity cimbined training (50-70% maximal heart rate reserve (HRR) and 50-70% 1 repetition maximom (1RM)), three times a week, for 12 weeks and each session 60 minutes. Each session consi

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: 1) BMI> 25 2) Menopause 3) No skeletal disease 4) Diabetes history of at least 4 years 5) Diagnosis of moderate depression by Beck test (score above 20) 6) blood pressure 160 to 95 mm Hg (maximum) 7) Age of menopause to 75 years 8) sedentary lifestyle for at least 6 months 9) glycemic control drugs 10) no metabolic conditions other than type 2 diabetes 11) fasting blood sugar at least 126

Exclusion criteria

Exclusion criteria: 1) Insulin therapy 2) Infectious disease 3) Skeletal disease 4) 3 sessions of no training 5) Malignant or known dementia 6) Metabolic conditions other than T2DM

Design outcomes

Primary

Measure	Time frame
basal BDNF levels(pre test,post test,detraining) Beck test score(pre test,post test,detraining) fat percentage(pre test,post test,detraining) basal insulin levels(pre test,post test,detraining) fasting blood glucose levels(pre test,post test,detraining)	—

Countries

Asia(except Japan)

Contacts

Public ContactElina Kiani Shahvandi

Shahrood University of Technology Sport Science,Sport physiology

elina.kiani@shahroodut.ac.ir00989364747539

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026