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Elucidation of a novel mechanism of metformin action through the gastrointestinal tract

Elucidation of a novel mechanism of metformin action through the gastrointestinal tract - Elucidation of a novel mechanism of metformin action through the gastrointestinal tract

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000039517
Enrollment
5
Registered
2020-03-31
Start date
2020-04-21
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 diabetes

Interventions

At the time of an FDG-PET / MRI examination pre-determined in routine medical care, we additionally take an MR enterography.

Sponsors

Kobe University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Patients with type 2 diabetes 2. Patients taking metformin hydrochloride 3. Patients who have been determined to take an FDG-PET / MRI by routine medical care 4. Patients with no obvious lesions in the lower gastrointestinal tract 5. Patients aged 20 years or older at the time of consent 6. Patients who have given their informed consent to participate in this study

Exclusion criteria

Exclusion criteria: 1. Patients who participated in other clinical trials within 4 months 2. Patients suffering from dementia or psychiatric disorders 3. Patients with possible intestinal perforation or obstruction 4. Other patients judged inappropriate by the person in charge of this study

Design outcomes

Primary

MeasureTime frame
The amount of excretion of FDG into the intestinal lumen

Secondary

MeasureTime frame
Correlation between FDG excretion and various clinical parameters such as HbA1c and blood glucose level

Countries

Japan

Contacts

Public ContactJun Ito

Kobe University Graduate School of Medicine Department of Internal Medicine Division of Diabetes and Endocrinology

karen@med.kobe-u.ac.jp078-382-5861

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026