Conservative versus liberal oxygenation targets in patients undergoing one-lung ventilation during thoracic surgery for lung resection: A Pilot single-center randomized controlled trial

Conservative versus liberal oxygenation targets in patients undergoing one-lung ventilation during thoracic surgery for lung resection: A Pilot single-center randomized controlled trial - Conservative versus liberal oxygenation targets in patients undergoing one-lung ventilation

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000039461

Enrollment

170

Registered

2020-04-01

Start date

2020-04-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lung cancer

Interventions

Conservative group (Intervention) Target oxygen saturation as measured by pulse oximetry (SpO2) of 90-94% during surgery Liberal group (Control) Target oxygen saturation as measured by pulse oximetr

96% during surgery

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Undergoing thoracic surgery for lung resection 2. Undergoing one-lung ventilation during general anesthesia 3. Adult aged 20 years or greater 4. Giving informed consent

Exclusion criteria

Exclusion criteria: 1. Bilateral lung resection 2. Receiving surgery with one-lung ventilation during the past one month 3. Estimated surgery time <2 hours 4. ASA physical status =>4 5. Known chronic obstructive pulmonary disease 6. Urgent or time-critical surgery 7. Severe anemia (hemoglobin <8 g/dL) 8. Judged inappropriate for participation by the researchers

Design outcomes

Primary

Measure	Time frame
Radiological atelectasis score of the dependent lung just after surgery	—

Secondary

Measure	Time frame
Radiological atelectasis score of the dependent lung on postoperative day (POD)1 PaO2/FIO2 ratio just after surgery and on POD1 Time-weighted average of SpO2 and FIO2 during surgery Sequential Organ Failure Assessment (SOFA) score on POD1 and POD2 Postoperative complications within 7 days following surgery (Clavien-Dindo classification grade =>III) AKI within 2 days following surgery (defined using KDIGO creatinine criteria) Hospital-free days at 28 days Hypoxemia during surgery (SpO2 <88% continues for more than 2min) *Severe hypoxemia during surgery (SpO2 =<85% continues for more than 2min)	—

Measure

Time frame

*Radiological atelectasis score of the dependent lung on postoperative day (POD)1 *PaO2/FIO2 ratio just after surgery and on POD1 *Time-weighted average of SpO2 and FIO2 during surgery *Sequential Organ Failure Assessment (SOFA) score on POD1 and POD2 *Postoperative complications within 7 days following surgery (Clavien-Dindo classification grade =>III) *AKI within 2 days following surgery (defined using KDIGO creatinine criteria) *Hospital-free days at 28 days *Hypoxemia during surgery (SpO2 <88% continues for more than 2min) *Severe hypoxemia during surgery (SpO2 =<85% continues for more than 2min)

—

Countries

Japan

Contacts

Public ContactSatoshi Suzuki

Okayama University Hospital Department of Intensive Care

suzuki-s@mtc.biglobe.ne.jp086-235-7330

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026