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Randomized Trial of Multiplex real-time PCR-based antibiotic therapy for severe bloodstream infections

Randomized Trial of Multiplex real-time PCR-based antibiotic therapy for severe bloodstream infections - Randomized Trial of Multiplex real-time PCR-based antibiotic therapy for severe bloodstream infections

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000039433
Enrollment
150
Registered
2020-02-08
Start date
2020-02-08
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

bacteremia

Interventions

1) Intervention 1 Antibiotic therapy based on the microorganism identification by conventional method and Filmarray system 2) Intervention 2 Antibiotic therapy based on the microorganism identificat

Sponsors

Hitachi General Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1) Patients with positive blood cultures who are hospitalized in the incentive care unit or high care unit in the Hitachi General Hospital. 2) Patients whose antibiotic treatment intensivists and antibiotic stewardship team choose.

Exclusion criteria

Exclusion criteria: 1) Suspected persistent bacteremia (positive blood cultures of the same bacteria based on gram stain examination) within the past week. 2) If no bacteria is shown on gram stain examination despite positive blood cultures. 3) If more than 48 hours have passed after positive blood cultures. 4) Receiving palliative care without antibiotic therapy. 5) If patients are not hospitalized in the ICU/HCU (due to death or transfer to another hospital/department).

Design outcomes

Primary

MeasureTime frame
Duration between the identification of positive blood cultures and the initiation of appropriate antibiotic therapy.

Secondary

MeasureTime frame
1) 28 day-mortality 2) Duration of ICU stay 3) Duration of hospital stay 4) Total cost of antimicrobial agents

Countries

Japan

Contacts

Public ContactHideki Hashimoto

Hitachi General Hospital Division of Emergency and Intensive Care Medicine/Department of Infectious Diseases

hidehashimoto-tky@umin.ac.jp81-0294-23-1111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026