Clinical study on the effect of lactic acid bacterium WB21 on prognosis of dental implant

Clinical study on the effect of continuous intake of Lactobacillus salivarius WB21 on maintaining the health of tissues around dental implants - Effect of continuous intake of Lactobacillus salivarius WB21 on tissues around dental implants

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000039392

Enrollment

Registered

2022-03-31

Start date

2020-04-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dental outpatient with dental implant

Interventions

Licking without chewing Lactobacillus salivarius WB21 tablet after eating and oral cleaning, 3 times a day, 1 tablet at a time. Licking without chewing placebo tablet after eating and oral cleaning, 3

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients undergoing implant treatment for molars at the Department of Oral Implantology, Fukuoka Dental College Medical and Dental Hospital, and currently undergoing maintenance

Exclusion criteria

Exclusion criteria: (1) Allergy to dairy products (2) Persons with poor general condition (3) Person who smokes habitually (4) Alcoholics (5) Pregnant and nursing women (6) Those who took antibiotics within 3 months (7) Others who are deemed inappropriate by the researcher

Design outcomes

Primary

Measure	Time frame
Implant site plaque index (PlI), gingival inflammation index (MGI), periodontal pocket (PPD), probing bleeding (BOP), secretory IgA in saliva	—

Secondary

Measure	Time frame
Questionnaire survey	—

Countries

Japan

Contacts

Public ContactNao Taniguchi

Fukuoka Dental College Department of Preventive and Public Health Dentistry

naojsz@college.fdcnet.ac.jp092-801-0411

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026