Investigation of the relationship between immune system and coagulation system in patient with cardiac arrest outside the hospital

Investigation of the relationship between innate immune responses and coagulofibrinolytic responses in patients with out-of-hospital cardiac arrest - Investigation of the relationship between innate immune responses and coagulofibrinolytic responses in patients with out-of-hospital cardiac arrest

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000039242

Enrollment

120

Registered

2020-01-23

Start date

2018-09-03

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Out-of-hospital cardiac arrest

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients who are 20 years of age or older at the time of obtaining consent Patients who died without return of spontaneous circulation after out-of-hospital cardiac arrest Patients who get return of spontaneous circulation Investigators have to get informed consent from the patients or their legal authorized representatives after explaining the participation in this study to them and confirming their understanding.

Exclusion criteria

Exclusion criteria: Patients with cardiac arrest due to trauma, acute aortic dissection or ruptured aortic aneurysm Patients who take anticoagulants Patients with coagulofibrinolytic disorders as underlying diseases Other patients who are judged inappropriate by the principal investigator

Design outcomes

Primary

Measure	Time frame
Severity of organ dysfunction, assessed by Sequential Organ Failure Assessment (SOFA) score	—

Secondary

Measure	Time frame
The levels of histone H3, interleukin-6, and various markers of coagulation and fibrinolysis Outcome (organ dysfunction, 28-days mortality and hospital death) Impact of DIC on outcome	—

Countries

Japan

Contacts

Public ContactTakeshi WADA

Hokkaido University Hospital Department of Emergency Medicine

twada1@med.hokudai.ac.jp011-706-7377

Outcome results