Double-blind and placebo-controlled crossover trial on the efficacy of tablets containing Lactobacillus rhamnosus L8020 for oral condition

Double-blind and placebo-controlled crossover trial on the efficacy of tablets containing Lactobacillus rhamnosus L8020 for oral condition - Effect of tablets containing Lactobacillus rhamnosus L8020 on oral condition

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000039070

Enrollment

Registered

2020-01-08

Start date

2020-01-09

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Oral condition

Interventions

Administration of one tablet containig the L8020 every day after lunch for one month Administration of one placebo tablet without the L8020 every day after lunch for one month

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Healty adults who belonging to Hyogo Prefecture Health Promotion Association, also who can receive dental checkups 2. Aged more that 30 less than 70 years old 3. Subjects who obtain written consent from themselves 4. Subjects whose have own 20 teeth or more

Exclusion criteria

Exclusion criteria: 1. Subjects who are scheduled to receive dental treatment (except for treatment without oral hygiene) during the study period 2. Smokers 3. Subjects in pregnancy 4. Subjects who regularly use antibiotics 5. Subjects with diseases affecting breath odor (Sjogren's syndrome, sinusitis, other systemic diseases, etc.) 6. Subjects with oral implants 7. Subjects with dentures (4 or more teeth on one side) 8. Participants in other clinical studies (including clinical trials) 9. Subjects who are considered unsuitable for this study by the investigator

Design outcomes

Primary

Measure	Time frame
Numbers of bacteria and their microflora analysis in oral plaque Oral condition (GI, PPD, BOP)	—

Secondary

Measure	Time frame
Salivary test Breath odor Experience and feeling effects in body	—

Countries

Japan

Contacts

Public ContactHideki Kosaka

Fujicco Co., Ltd. Research and Development Department

h-kosaka@fujicco.co.jp078-303-5385

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026