Studies on Pathophysiology and Possible Cause of Hie-Symptom -Findings on Sublingual and Body Surface Temperature, Venous Gas Partial Pressure and the Effects of Oral Administration of PDE-5 Inhibitor Tadarafil-

Studies on Pathophysiology and Possible Cause of Hie-Symptom -Findings on Sublingual and Body Surface Temperature, Venous Gas Partial Pressure and the Effects of Oral Administration of PDE-5 Inhibitor Tadarafil- - Studies on Pathophysiology and Possible Cause of Hie-Symptom

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000039008

Enrollment

Registered

2019-12-26

Start date

2017-12-09

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hie-Symptom

Interventions

The subjects were 17 women under the age of 50 who had no special history of disease (stroke, myocardial infarction, cancer, diabetes, etc.) or medication and had not reached menopause working as a ho

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: The subjects are women under the age of 50 who have no special history of disease (stroke, myocardial infarction, cancer, diabetes, etc.) or medication and have not reached menopause. Those who have a coldness and those who are not.

Exclusion criteria

Exclusion criteria: Postmenopausal Women

Design outcomes

Primary

Measure	Time frame
The subjects were BMI,blood pressure, heart rate,sublingual and peripheral body surface temperature (hand and lower limb),venous and arterial blood gas partial pressure, and fingertip arterial oxygen saturation were measured. The measurement was carried out at warm indoors (about 23.) and cold outdoors (about 12.). Then 10 mg TDF tablet was taken and all measurements were repeated again at the same time on the next day.	—

Measure

Time frame

The subjects were BMI,blood pressure, heart rate,sublingual and peripheral body surface temperature (hand and lower limb),venous and arterial blood gas partial pressure, and fingertip arterial oxygen saturation were measured. The measurement was carried out at warm indoors (about 23.) and cold outdoors (about 12.). Then 10 mg TDF tablet was taken and all measurements were repeated again at the same time on the next day.

—

Secondary

Measure	Time frame
The subjects were BMI,blood pressure, heart rate,sublingual and peripheral body surface temperature (hand and lower limb),venous and arterial blood gas partial pressure, and fingertip arterial oxygen saturation were measured. The measurement was carried out at warm indoors (about 23.) and cold outdoors (about 12.). Then 10 mg TDF tablet was taken and all measurements were repeated again at the same time on the next day.	—

Measure

Time frame

—

Countries

Japan

Contacts

Public ContactTsubasa Minagawa

Okubo Hospital Department of Rehabilitation

reha@okubo-hp.com0974-64-7777

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026