A randomized, double-blind, placebo- controlled, parallel-group study on the effect of N-acetylglucosamine on discomfort in the knee.

A randomized, double-blind, placebo- controlled, parallel-group study on the effect of N-acetylglucosamine on discomfort in the knee. - Effect of N-acetylglucosamine on discomfort in the knee.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000038859

Enrollment

100

Registered

2019-12-15

Start date

2019-12-16

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy adults

Interventions

Ingestion of supplement containing N-acetylglucosamine for 12 weeks. Ingestion of placebo without N-acetylglucosamine for 12 weeks.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Healthy males and females aged 20 to 69 years old 2. Subjects who experience discomfort or pain in the knee and are classified into 0-I grade based on the Kellgren-Lawrence classification 3. Individuals who can make self-judgment and are voluntarily giving written informed consent

Exclusion criteria

Exclusion criteria: 1. Individuals who are under treatment, have a history, or are suspected to have rheumatoid arthritis 2. Individuals who need treatment and medication for osteoarthritis 3. Individuals with history of surgical therapy (artificial joint) on knees. 4. Individuals who continuously use compress, topical cream, and/or analgesic agent etc. on knee region 5. Individuals who have injury of semi-lunar disc or the other knee joint disease 6. Individuals who are under treatment of serious chronic diseases e.g., liver disease, heart and/or vascular disease, respiratory disorder, endocrine disorder, or metabolic diseases 7. Individuals who cannot stop using supplements and/or functional foods affecting knee cartilage 8. Individuals who have a history of food allergy 9. Individuals who hope for pregnancy in the test duration, pregnant women, lactating women 10. Individuals who are planning to participate or already participating in other clinical studies 11. Individuals who are judged as unsuitable for the study by the investigator for other reasons

Design outcomes

Primary

Measure	Time frame
JOA Score	—

Secondary

Measure	Time frame
JKOM Scor, Knee joint subjective symptoms (VAS), KS Score, J-KOOS Interview, Body weight, Blood pressure, Pulse rate, Subjective and objective symptoms, Adverse events, Hematologic test, Blood biochemistry test, Urine analysis	—

Countries

Japan

Contacts

Public ContactEiji Yoshikawa

KSO Corporation Sales department

yoshikawa@kso.co.jp03-3452-7733

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026