The impact of Goal-Directed Prehabilitation Therapy on the functional capacity in patients undergoing highly invasive surgery. A randomized controlled study

The impact of Goal-Directed Prehabilitation Therapy on the functional capacity in patients undergoing highly invasive surgery. - The impact of Goal-Directed Prehabilitation Therapy on the functional capacity in patients undergoing highly invasive surgery.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000038791

Enrollment

180

Registered

2019-12-04

Start date

2019-12-04

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients who are going to undergo a highly invasive abdominal surgery.

Interventions

Goal-directed prehabilitation therapy Conventional prehabilitation therapy

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients who are going to undergo a highly invasive surgery in Nagoya University Hospital Surgery I and II. Highly invasive surgery includes; 1. Major hepatectomy 2. Hepatopancreatoduodenectomy 3. Pancreatoduodenectomy 4. Destal pancreatectomy with celiac axis resection 5. Other highly invasive surgeries with similar invasion as above procedures

Exclusion criteria

Exclusion criteria: Patients who rejected to participate this study. who can not do exercise. who has a congenital metabolic disorder for the branched chain amino acids. who undergo emergent surgery. who are with severe complications. who are with mental disorder. who are with cognitive disorder. who have a risk of fall. who are not eligible for the study determined by the investigators.

Design outcomes

Primary

Measure	Time frame
To compare the nutritional status, host immune function, intestinal microbitota, fecal organic acids concentrations, muscle mass, fat mass, and exercise capacity between conventional prehabilitation group and goal-directed prehabilitation group.	—

Secondary

Measure	Time frame
1. To Compare the incidence of postoperative complications and the length of postoperative hospital stay. 2.To investigate the correlation between the preoperative conditions including nutritional status, host immune function, intestinal microbiota, fecal organic acids concentrations, muscle mass, fat mass, and functional exercise capacity and the incidence of postoperative complications and the length of postoperative hospital stay. 3.To compare the long term outcome after surgery between Synbiotics and Synbio-Prehabilitation groups. 4.To investigate the impact of preoperative nutritional status, host immune function, intestinal microbiota, fecal organic acids, muscle mass, fat mass, and functional exercise capacity on the long term outcome after surgery.	—

Measure

Time frame

1. To Compare the incidence of postoperative complications and the length of postoperative hospital stay. 2.To investigate the correlation between the preoperative conditions including nutritional status, host immune function, intestinal microbiota, fecal organic acids concentrations, muscle mass, fat mass, and functional exercise capacity and the incidence of postoperative complications and the length of postoperative hospital stay. 3.To compare the long term outcome after surgery between Synbiotics and Synbio-Prehabilitation groups. 4.To investigate the impact of preoperative nutritional status, host immune function, intestinal microbiota, fecal organic acids, muscle mass, fat mass, and functional exercise capacity on the long term outcome after surgery.

—

Countries

Japan

Contacts

Public ContactYukihiro Yokoyama

Nagoya Unviersity Graduate School of Medicine Division of Gastrointestinal Surgery, Department of Surgery

yyoko@med.nagoya-u.ac.jp052-744-2222

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026