Multicenter retrospective study to examine the efficacy of intervention by healthcare providers for hand-foot skin reaction that occurred after sorafenib use for patients with advanced hepatocellular carcinoma

Multicenter retrospective study to examine the efficacy of intervention by healthcare providers for hand-foot skin reaction that occurred after sorafenib use for patients with advanced hepatocellular carcinoma - Multicenter retrospective study to examine the efficacy of intervention by healthcare providers for hand-foot skin reaction that occurred after sorafenib use for patients with advanced hepatocellular carcinoma

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000038701

Enrollment

130

Registered

2019-11-27

Start date

2019-06-03

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

advanced hepatocellular carcinoma

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Indication criteria for sorafenib included the following: (1) Child-Pugh grade, A or B; (2) Eastern Cooperative Oncology Group Performance Status, 0 or 1; (3) hemoglobin level, not less than 8.5 g per dL; (4) neutrophil count, more than 1500 per microliter; (5) platelet count, more than 75000 per microliter; (6) total bilirubin level, less than 2.0 mg per dL; (7) alanine and aminotransferases, less than 5-fold the upper limit of the normal range; and (8) no necessity for dialysis.

Exclusion criteria

Exclusion criteria: Exclusion criteria included the following: (1) A history of serious hypersensitivity to the components of this drug; (2) pregnant women or those who may be pregnant; (3) a history of thrombosis or ischemic heart disease; and (4) brain metastasis.

Design outcomes

Primary

Measure	Time frame
overall survival	—

Countries

Japan

Contacts

Public ContactToshiro Kamoshida

Hitachi General Hospital Department of Gastroenterology

toshiro.kamoshida.fu@hitachi.com0294231111

Outcome results