Down syndrome eGFR<
Conditions
Interventions
All children are hospitalized for 2 days and examined. The same person is not measured repeatedly only once for each subject. The amount of drugs and fluid replacement is calculated based on the weig
s solution load of 20 ml/kg body weight for 30 min to obtain good diuresis, following by a load of 5 ml/kg/h until testing completion. From 30 min after water loading, inulin give intravenously in a p
s formula. Therefore, the patients received an inulin load of 0.7 * eGFR ml/m2/h with calculation of body surface area by the Haycock method. We collect Urine samples in two periods of 1 h each, and b
Sponsors
Division of Nephrology, Saitama Children's Medical Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Meets all of the following Down syndrome 2 to 18 years old eGFR<90 ml/min/1.73m2: Uemura's formula
Exclusion criteria
Exclusion criteria: Any one of the following congenital anomalies of the kidney and urinary tract chronic glomerulonephritis Respiratory or heart failure requiring oxygen administration Under treatment for gastrointestinal symptoms and infectious diseases, inflammatory diseases Women who are pregnant or may be pregnant neuromuscular disease, muscle disease Mental disorders Immune disorder malformation syndrome other than Down syndrome Abnormal separate quantitative renal function (more than 20% left-right difference) In this study, which the ratios of urine inulin excretion and intravenous inulin administration were <0.5 or >1.5 In this study, glomerular filtration rate >150 ml/min/1.73m2
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| inulin clearance Blood test: creatinine, inulin Before test start, 30 minutes after start, 90 minutes later Urinalysis: creatinine, inulin Before test start, at start, after 60 minutes, after 120 minutes | — |
Secondary
| Measure | Time frame |
|---|---|
| Gender, age, height, complications Blood test: Cystatin C, B2MG Urinalysis: B2MG separate quantitative renal function: 99mTc-DMSA Congenital anomalies of the kidney and urinary tract: Abdominal ultrasonography Comparison with eGFR obtained from Uemura's formula | — |
Countries
Japan
Contacts
Public ContactTomohiko Nishino
Saitama Children's Medical Center Division of Nephrology
Outcome results
None listed