Japan-multimodal intervention Trial for prevention of dementia (J-MINT)

Conditions

Older adults with cognitive impairment.

Sugimoto T, Uchida K, Yokoyama Y, Onoyama A, Noma H, Arai H, Sakurai T, J‐MINT study group.

2025-11-01

Adherence and aerobic exercise intensity in live online exercise sessions for older adults with mild cognitive impairment: Insights from the Japan-Multimodal Intervention Trial for the Prevention of Dementia.

Sugimoto T, Uchida K, Yokoyama Y, Onoyama A, Fujita K, Kuroda Y, Hinakura K, Ogawa S, Suzuki H, Fujiwara Y, Crane PK, Arai H, Sakurai T, J-MINT study group.

2025-02-071 citations

10.1016/j.jarlif.2025.100003

Factors associated with adherence to tablet‐based cognitive training: J‐MINT study

Taiki Sugimoto, Kazuaki Uchida, Kenji Sato, Yoko Yokoyama, Ayaka Onoyama et al. (11 authors)

Alzheimer s & Dementia Translational Research & Clinical Interventions2025-01-012 citations

10.1002/trc2.70062

Interventions

Multidomain intervention including the magement of lifestyle-related disease, exercise, nutritional guidance, and cognitive training. Diabetes, hypertension, and dyslipidemia will be treated accordi

Brain HQ&quot

will be provided by using iPad. Usual care. Providing documents regarding lifestyle and behaviors for the prevention of dementia.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Subjects who 1) aged 65-85 at the time of enrollment. 2) have age-adjusted decline at least SD of 1.0 from the reference threshold in any cognitive domains measured by using NCGG-FAT. 3) have provided a written informed consent on this study and biobank project* by subjects. *: Only for subjects recruited from the NCGG.

Exclusion criteria

Exclusion criteria: Subjects who 1) are needed to restrict any physical exercise and/or diet due to functional decline, including presence of bone or joint disease, renal faiure, ischemic heart disease, and cardiopulmonary disorders. 2) are diagnosed with dementia. 3) have a MMSE score of less than 24. 4) are unable to speak in Japanese. 5) are unable to perform cognitive tests. 6) have a care-needs certification in the long-term care insurance system. 7) are deemed ineligible for enrollment by the responsible researcher or co-researcher at each institution.

Design outcomes

Primary

Measure	Time frame
Change in a composite score of cognitive function from baseline to a 18-month follow-up.	—

Secondary

Measure	Time frame
1) Changes in a composite score of cognitive tests from baseline to a 6/12-month follow-up. 2) Changes in scores of each cognitive test from baseline to a 6/12/18-month follow-up. 3) Changes in laboratory and urinary markers from baseline to a 6/18-month follow-up. 4) Changes in ADL scores from baseline to a 6/18-month follow-up. 5) Changes in the status of frailty from baseline to a 6/18-month follow-up. 6) Changes in brain images assessed using MRI or CT from baseline to a 18-month follow-up. 7) Changes in the number of medications. 8) Changes in each result of a comprehensive geriatric assement from baseline to a 6/18-month follow-up. 9) Incident dementia.	—

Measure

Time frame

1) Changes in a composite score of cognitive tests from baseline to a 6/12-month follow-up. 2) Changes in scores of each cognitive test from baseline to a 6/12/18-month follow-up. 3) Changes in laboratory and urinary markers from baseline to a 6/18-month follow-up. 4) Changes in ADL scores from baseline to a 6/18-month follow-up. 5) Changes in the status of frailty from baseline to a 6/18-month follow-up. 6) Changes in brain images assessed using MRI or CT from baseline to a 18-month follow-up. 7) Changes in the number of medications. 8) Changes in each result of a comprehensive geriatric assement from baseline to a 6/18-month follow-up. 9) Incident dementia.

—

Countries

Japan

Contacts

Public ContactHidenori Arai

National Center for Geriatrics and Gerontology Department of Geriatric Medicine

jmint@ncgg.go.jp0562-46-2311

Outcome results

None listed