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Longitudinal change on the skin barrier functions by application of moisturizers: an experimental study

Longitudinal change on the skin barrier functions by application of moisturizers: an experimental study - Longitudinal change on the skin barrier functions by application of moisturizers: an experimental study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000038647
Enrollment
24
Registered
2019-11-20
Start date
2019-11-12
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

non-atopic adults, atopic dermatitis

Interventions

Apply about 0.5g of Pigeon Baby Cream f on one forearm and Pigeon Vaseline on the other forearm. Apply once a day after bathing and continue daily for 28 days (+7 days) until the end of the third meas

Sponsors

National Center for Child Health and Development
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Those who are 20 years of age or older when obtaining consent

Exclusion criteria

Exclusion criteria: 1) Those who have been diagnosed with allergies to moisturizers 2) Those who have taken steroids or immunosuppressants for one month prior to registration 3) Those who have used topical steroids or tacrolimus for the forearm within one month before registration 4) Participants in other usage tests 5) Those who are determined to be inappropriate for study participation by the study doctor or study director

Design outcomes

Primary

MeasureTime frame
1. Water content of stratum corneum and specific molecules (natural moisturizing factor, urea, urocanic acid, ceramide, cholesterol, etc.) measured by confocal Raman spectroscopy.

Secondary

MeasureTime frame
2. Stratum corneum pH 3. Water content of stratum corneum 4. TEWL

Countries

Japan

Contacts

Public ContactNaoko Mochimaru

National Center for Child Health and Development Division of Dermatology

skin_research@ncchd.go.jp03-3416-0181

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026