The Relationship between Periodontitis and Atherosclerosis in Patients with Acute Coronary Syndrome and The Impact for Periodontal Treatment to Atherosclerosis: A Prospective Observational Study

The Relationship between Periodontitis and Atherosclerosis in Patients with Acute Coronary Syndrome and The Impact for Periodontal Treatment to Atherosclerosis: A Prospective Observational Study - The Relationship between Periodontitis and Atherosclerosis in Patients with Acute Coronary Syndrome and The Impact for Periodontal Treatment to Atherosclerosis: A Prospective Observational Study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000038606

Enrollment

100

Registered

2019-11-18

Start date

2019-08-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Artery Disease

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Those undergoing coronary angiography or revascularization at acute coronary syndrome 2. Those who are 20 years of age or older when obtaining consent 3. Those who have received sufficient explanation for participation in this study, and who have fully understood and have given the written consent of the research subject. (However, in cases where it is difficult to obtain consent from the person due to dementia, etc., consent by relatives within two relatives is permitted.) 4. Those with a high risk of periodontal disease (those with oral symptoms, those with a clearly small number of teeth, those with arteriosclerosis risk such as smoking and diabetes)

Exclusion criteria

Exclusion criteria: 1. Those who applied for refusal to participate in this study 2. Those who are difficult to conduct coronary angiography due to general condition, advanced dementia, etc. 3. Those who are deemed inappropriate by the principal investigator

Design outcomes

Primary

Measure	Time frame
The severity of periodontitis and the complexity of coronary lesions(SYNTAX Score, ACC/AHA morphological classification), Correlation of degree of yellow plaque on coronary angioscopy, and The severity of periodontitis and the complexity of coronary lesions (SYNTAX Score, ACC/AHA morphological classification) in the chronic phase (after periodontal treatment or dental education if necessary), Rate of change in degree of yellow plaque on coronary angioscopy	—

Measure

Time frame

The severity of periodontitis and the complexity of coronary lesions(SYNTAX Score, ACC/AHA morphological classification), Correlation of degree of yellow plaque on coronary angioscopy, and The severity of periodontitis and the complexity of coronary lesions (SYNTAX Score, ACC/AHA morphological classification) in the chronic phase (after periodontal treatment or dental education if necessary), Rate of change in degree of yellow plaque on coronary angioscopy

—

Secondary

Measure	Time frame
1. Relationship between periodontitis and degree of plaque on aortic angioscopy 2. Relationship between periodontitis and evaluation of arteriosclerotic changes by other tests (optical coherence tomography: OCT, coronary flow reserve: CFR, carotid echo, cardiac magnetic resonance imaging: MRI, etc.)	—

Countries

Japan

Contacts

Public ContactRikku Arai

Division of Cardiology, Department of Medicine, Nihon University School of Medicine Cardiology

arai.riku@nihon-u.ac.jp+81-3-3972-8111

Outcome results