A Study of the Probability and Course of Jaw Corruption by Drugs: Observations in Patients with Lung Cancer and Bone Metastases in Multiple Facilities

Incidence and treatment outcomes of medication-related osteonecrosis of the jaw: A prospective observational multicenter study of patients with primary lung cancer and bone metastases - RING-ML01

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000038586

Enrollment

300

Registered

2019-11-14

Start date

2019-11-18

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

medication-related osteonecrosis of the Jaw

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: (1) Patients with primary lung cancer (2) Patients scheduled to receive BMA for bone metastases (3) Patients who understand the contents of the study and are capable of providing written informed consent

Exclusion criteria

Exclusion criteria: (1) Patients with a history of BMA use for bone metastases (2) Patients with past or present osteomyelitis or osteonecrosis of the jaw (3) Patients with jawbone lesions such as jawbone metastases (4) Patients with a history of receiving radiation therapy in the jawbone (5) Patients who have developed head and neck cancer or have a history of it (6) Patients judged to be inappropriate by the principal investigator or subinvestigator

Design outcomes

Primary

Measure	Time frame
Occurrence rate of MRONJ in patients with primary lung cancer and bone metastases	—

Countries

Japan

Contacts

Public Contactmaiko shimosato

National Hospital Organization Kyoto Medical Center oral and maxillofacial surgery

maikoshimosato0629@hotmail.co.jp075-641-9161

Outcome results