Efficacy, safety and effects on depth of anesthesia of transcutaneous vagus nerve stimulation during general anesthesia

Efficacy, safety and effects on depth of anesthesia of transcutaneous vagus nerve stimulation during general anesthesia - Efficacy, safety and effects on depth of anesthesia of transcutaneous vagus nerve stimulation during general anesthesia

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000038456

Enrollment

Registered

2019-10-31

Start date

2019-10-31

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients who undergo surgery under general anesthesia

Interventions

Transcutaneous vagus nerve stimulation (5.0 mA) Sham stimulation (0 mA)

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients scheduling to undergo elective surgery under general anesthesia 2. Patients of American Society of Anesthesiologists physical status 1 3. Patients scheduling to undergo low cardiac risk surgery 4. Patients of normal sinus rhythm in preoperative electrocardiogram

Exclusion criteria

Exclusion criteria: 1. Patients schedules to undergo head and neck surgery 2. Patients with a history of vasovagal syncope 3. Patients with a history of arrhythmia 4. Patients with a history of surgery or trauma of the auricle, neck, chest or heart 5. Patients with injuries in the skin, subcutaneous tissue or muscle of the auricle or neck 6. Patients taking an antihypertensive, antiarrhythmic or psychotropic drug 7. Pregnant women or lactating women 8. Patients with a history of cerebral aneurysm treatment 9. Patients with implanted medical devices

Design outcomes

Primary

Measure	Time frame
Parameters of heart rate variability measurements	—

Countries

Japan

Contacts

Public ContactRyo Wakabayashi

Shinshu University School of Medicine Department of Anesthesiology and Resuscitology

waka0924@shinshu-u.ac.jp+81-263-37-2670

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026